Head of the lab:

Pr Antoine ROQUILLY, MD, PhD, research interest focuses on the settings of immunosuppression. Systemic inflammatory response syndrome (SIRS) is a common condition in trauma and septic patients. SIRS causes protracted immunosupression exposing the patients to severe secondary infections. Dendritic cells (DCs), which play a pivotal role bridging innate and T cell-dependent immunity, exhibit prolonged alterations after SIRS. We are studying the alterations in DC function post-SIRS. Understanding about the molecular mechanisms involved might open new therapeutic avenues to prevent or reduce protracted immunosuppression in trauma and brain-injured patients. 


Pr Karim Asehnoune got his degree as MD in 1999 at the University René Descartes in Paris, France. After completing his PhD in immunology in 2001, he spent one year in the lab of Edward Abraham in Denver, USA (2002). He was appointed Professor of Anaesthesiology and Critical Care Medecine in the University of Nantes in 2009. Professor Ashenoune is the head of the Anaesthesiology Department of the Hotel-Dieu Hospital and the director of the 30-bed surgical Intensive Care Unit at the University Hospital of Nantes, France. He is currently member of the scientific committee of the French Society of Anaesthesiology and Critical Care Medecine, and the director of a French network of ICUs (www.ATLANREA.org). Professor Asehnoune was involved as the coordinator of several multi-center trials. His main focuses of interest are pulmonary complications, and immunodepression-induced pneumonia after brain injuries. he has published more than 130 peer-reviewed articles.

Pr David Boutoille, MD, PhD, is a PU-PH at Nantes Hospital in the Infectious disease Department.
His research focus incudes the development of new antimicrobial therapies (antibiotics, phages).

Alexis Broquet, PhD, is a Nantes Hospital research engineer. Translating from rotavirus infection and celiac disease during his post-doctoral training at UC San Diego, he is now in charge of the evaluation of the host response during pneumonia challenge by using in vitro and in vivo models.

Jocelyne Caillon, PharmD, PhD, is Associate Professor (MCU-PH) in the Faculty of Medecine of the University of Nantes and the Head of the Bacteriology laboratory of the Centre Hospitalier Universitaire de Nantes. She has an extensive experience in bacterial resistance, in the in vitro activity of antibiotics, in the pharmacokinetics/pharmacodynamics (PK/PD) of the antibiotics and their efficacy in different animal models.

Pr Nathalie Caroff, PharmD, PhD, is Professor of Bacteriology at the Faculty of Pharmacy, where she is also in charge of international exchanges. She worked during many years on mechanisms of bacterial resistance to beta-lactams. She is currently interested in studying bacterial virulence factors involved in the immune response.

Dr Lise Cremet, PharmD, PhD, is a bacteriologist at Nantes Hospital and MCU-PH in bacteriology. Her research focuses on bacterial virulence and patho-adaptation.

Cédric Jacqueline, PhD, is a Research Engineer in the Unit "Clinical and Experimental Therapeutics of Infections" (EA3826, University of Nantes). Coming from the field of the in vivo evaluation of new therapeutic agents in animals models of infection (mice, rabbits), his current research focuses on the role of therapeutic strategies (antibiotics, phages, and immune adjuvants) in the modulation of innate immune response during Pseudomonas aeruginosa and Staphylococcus aureus-induced pneumonia.

Danila Valmori, PhD. 
Dr Mickaël Vourc'H, MD, PhD.

PhD students

  • Dr Marwan Bouras
  • Dr Anne Gaëlle Leroy

Administrative Department

Tel. +33 (0)2 53 00 91 81
 EA3826 - IRS2 Nantes Biotech - Room 201
22 Boulevard Benoni Goullin
44200 NANTES

Grant manager